A0835
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A0835
Sigma
N-Acetyl-Asp-Glu-Val-Asp-al
≥95%, powder
| Synonym: | Ac-DEVD-CHO |
| CAS Number: | 169332-60-9 |
| Linear Formula: | C20H30N4O11 |
| Molecular Weight: | 502.47 |
| MDL number: | MFCD00671412 |
| PubChem Substance ID: | 24890193 |
Description
| Biochem/physiol Actions | Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3). |
Properties
| assay | ≥95% |
| form | powder |
| color | white |
| solubility | H2O: 1 mg/mL |
| Gene Information | human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Nicholson, D.W., et al., Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43, (1995) |
| Harvey, K.J., Commitment and effector phases of the physiological cell death pathway elucidated with respect to Bcl-2 caspase, and cyclin-dependent kinase activities. Mol. Cell. Biol. 18, 2912-2922, (1998) | |
| Takahashi, M., et al., Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. Proc. Natl. Acad. Sci. U. S. A. 95, 11566-11571, (1998) | |
| Santoro, M.F., et al., Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis. J. Biol. Chem. 273, 13119-13128, (1998) | |
| Margonin, N., Substrate and inhibitor specificity of interleukin-1β converting enzyme and related caspases. J. Biol. Chem. 272, 7223, (1997) |
